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KMID : 0359920100290060796
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Korean Journal of Nephrology
2010 Volume.29 No. 6 p.796 ~ p.801
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Neurotoxicity Induced by Cefepime in a Patient with Minimal Change Disease
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Baek Seung-Don
Park Se-Jung
Baek Chung-Hee
Koo Tai-Yeon
Kang Joong-Koo
Kim Soon-Bae
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Abstract
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A 71-year-old woman with minimal change disease visited our clinic complaining of pleuritic chest pain. Cefepime was given under the impression that she had pneumonia. Three days after cefepime administration, she became unconscious. A brain MRI scan was non-revealing and an EEG showed triphasic waves. As there was no evidence of septic, uremic or hepatic encephalopathy, we suspected cefepime-induced neurotoxicity. Cefepime was stopped and she underwent hemodialysis to decrease the blood levels of the drug. Following hemodialysis, she regained consciousness.
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KEYWORD
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Cefepime, Neurotoxicity syndromes, Minimal change glomerulopathy, Hemodialysis
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